CeliAct(TIV) project aims to advance the knowledge on Celiac Disease pathophysiology by dissecting mechanisms of gluten-microbiota-immune system interactions.

One aim is to characterize the bacterial microbiota structure of Celiac Disease patients and their first-degree relatives. Are there distinct features in a Celiac Disease patient? What are these bacteria doing? Do they impact gluten digestion?

Another aim is to contribute to the understanding of gluten-microbiota-immune system interplay. Do bacteria influence gluten digests presentation to the immune system? Do they contribute to gut inflammation and gluten or bacteria translocation?

Avoiding gluten is currently the only method for thwarting intestinal damage, relieving symptoms and prevent complications. But eating even the tiniest fraction of gluten immediately re-triggers symptoms and intestinal damage in most Celiac Disease patients. Moreover, around 30% Celiac Disease patients still have symptoms despite avoiding gluten, having no alternative treatment for their disease.