What is the role of carotid bodies as a biomarker in prediabetes?

Maria Guarino and Marlene Lages co-author the book chapter “Carotid Bodies: Use of Chemosensitivity as a Biomarker in Prediabetes” which is included in the “Biomarkers in Disease: Methods, Discoveries and Applications” book series from Springer.
This one is a full chapter dedicated to the role of carotid bodies (CB) as metabolic sensors and the relevance of the overactivation of these organs in the development of prediabetes and type 2 diabetes (T2D).
The authors claim that it is possible to understand carotid body activity by measuring a set of physiological variables, allowing to identify people with subclinical alterations associated with the development of prediabetes.
Besides, hyperinsulinemia, hyperleptinemia, and inflammation contribute to CB overactivation leading to an increase in sympathetic nervous system activity promoting the development of metabolic diseases such as metabolic syndrome, obesity and T2D.