Understanding the association between chronotype, mealtiming and circadian biomarkers

Obesity and associated comorbidities are among the main causes of death worldwide. Prevention of overweight and obesity, as well as innovative lifestyle interventions directed towards improving metabolic homeostasis, are first-line strategies for treatment and are crucial to reducing the obesity burden.
The NutriClock project proposes a multidimensional approach to better understand obesity phenotypes, based on chronobiology features assessment. Our aim is to screen individual circadian variations and clock gene expression and correlate them with the heterogeneous clinical phenotypes of obesity.
To accomplish its objectives, the research project comprises a series of multidisciplinary tasks centred on an observational clinical study conducted in a group of patients with obesity and a control group with healthy participants.

Keywords: Chrononutrition; Obesity; Circadian rhythms

Principal Investigator: Maria Guarino

Team Members and Affiliations
Marlene Lages
Renata Barros: Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto;
Sara Carmo-Silva: Escola Superior de Tecnologia da Saúde de Coimbra.

Duration: 2019 – 2024

Institutional Partners and Others

  • Faculdade de Ciências da Nutrição e Alimentação da Universidade do Porto;
  • Unidade Local de Saúde – Região de Leiria;
  • Coimbra Health School, Polytechnic University of Coimbra.

Funding:  Emilio Peres Award 2020 – Portuguese Society of Diabetology