GENetic and clinIcAL markers in COPD trajectory

GENIAL aims to determine the role of genetic mutations associated with the development and trajectory of COPD and to identify the clinical markers (e.g., dyspnea, number of exacerbations, lung function, exercise tolerance) capable of detecting acute exacerbations of COPD (AECOPD). Specifically, the project aims to:
1-Characterize clinical markers and 13 genes and explore their associations in patients with COPD;
2-Define clinical and genetic differences between patients with COPD and healthy people;
3-Determine the role of the mutations of the 13 genes in the behavior of clinical markers over time in patients with COPD;
4-Investigate the sensitivity of clinical markers to detect AECOPD and changes in patients’ health status, over time;
5-Investigate the impact of the genetic profile in the effectiveness of the physiotherapy in AECOPD.

Investigator at IPLeiria
Joana Cruz

Principal Investigator
Alda Marques

36 months (2016 – 2019)

Leading institution
University of Aveiro